Annoying - drugs whose pharmacological effect is mainly due to the stimulating effect on the endings of the afferent nerves of the skin and mucous membranes.
Examples of irritants: ammonia solution (ammonia), menthol (from peppermint leaves), mustard essential oil (from mustard seeds), turpentine essential oil (gum turpentine), pepper patch (capsicum fruits containing capsaicin), Arnica flowers, eucalyptus oil, salicylic acid methyl ester, snake and bee poisons, 40% ethyl alcohol.
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Some synthetic substances and products of plant origin are referred to irritants. Of the synthetic substances, ammonia, formic acid, ethyl alcohol, dichloroethyl sulfide (mustard), trichlorotriethylamine, methyl salicylate, nicotinic acid derivatives (for example, nicotinic acid b-butoxyethyl ester, ethyl nicotinate) and others possess these irritating properties. These substances are used as irritants various dosage forms intended for external use. For example, ammonia is used as an ammonia solution (Solutio ammonii caustici) and liniment ammonia (Linimentum ammoniatum, synonym for “volatile ointment”), formic acid - in the form of formic alcohol (Spiritus Acidi formici), which is a mixture of 1 part of formic acid and 19 parts of 70% ethyl alcohol. Dichlorodiethyl sulfide is a part of Psoriazine ointment, trichlorotriethylamine is a part of Antipsoriaticum ointment, nicotinic acid b-butoxyethyl ester along with nonilinic acid vanillamide is a part of Finalgon ointment (Ounguentum finalgon), and ethyl nicotinate along with capsaicin, ethylene glycol salicylate and lavender oil are part of Nicoflex cream. Methyl salicylate is used per se or in a mixture with other irritating agents in a number of dosage forms, for example, Bohm-Bengue ointment (Unguentum Boum - Benge), a complex of methyl salicylate liniment (Linimentum methylii salicylatis compositum), liniment "Sanitas" (Linimentum "Sanitas"), salinimenta (Salinimentum).